April 2020 additions to NERDB part 2

April 2020 additions to NERDB part 2

NERDB is the New and emerging risks database. This bibliographic database is an initiative of Nicole Palmen and Annet Lenderink with the support of Modernet and is currently powered by Airtable.

More information on this database on the NERDB page

On the website we will publish from this month on regular updates on new disease – exposure combinations we added to the database. Currently, we have 231 entries. Ordered by year in which the abstract is published

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Last new entries

Aalto‐Korte, K, Koskela, K, Pesonen, M. 12‐year data on dermatologic cases in the Finnish Register of Occupational Diseases I: Distribution of different diagnoses and main causes of allergic contact dermatitisContact Dermatitis. 2020; 1– 6. https://doi.org/10.1111/cod.13488

Skin diseases are among the most common occupational diseases, but detailed analyses on their epidemiology, diagnoses, and causes are relatively scarce. To analyze data on skin disease in the Finnish Register of Occupational Diseases (FROD) for (1) different diagnoses and (2) main causes of allergic contact dermatitis (ACD). Data were retrieved on recognized cases with occupational skin disease (OSD) in the FROD from a 12-year-period 2005-2016 and used national official labor force data of the year 2012.

We analyzed a total of 5265 cases, of which 42% had irritant contact dermatitis (ICD), 35% ACD, 11% contact urticaria/protein contact dermatitis (CU/PCD), and 9% skin infections. The incidence rate of OSD in the total labor force was 18.8 cases/100 000 person-years. Skin infections concerned mainly scabies in health care personnel. Twenty-nine percent of the ACD cases were caused by plastics/resins-related allergens, mainly epoxy chemicals. Other important causes for ACD were rubber, preservatives, metals, acrylates, and hairdressing chemicals. Cases of occupational ACD due to isothiazolinones reached a peak in 2014. Our analysis confirms that epoxy products are gaining importance as causes of OSD and the isothiazolinone contact allergy epidemic has started to wane.

Poon J, Al-Halawani M, Dubey G. Spontaneous pneumothorax as a complication of chronic Jet propulsion fuel-8 exposure. Heart Lung. 2019 Mar-Apr;48(2):169-172. DOI: 10.1016/j.hrtlng.2018.08.001. Epub 2018 Sep 2.

Jet Propulsion Fuel 8 (JP-8) is a kerosene-based fuel commonly used in aviation. Occupational exposure to JP-8 may lead to negative health outcomes, which were described in a small number of studies. We report a case of a 33-year-old Caucasian male veteran with a history of JP-8 exposure who presented with chronic dyspnea and recurrent spontaneous pneumothorax. To our knowledge, this is the first case of chronic inhalation injury from JP-8 exposure complicated with recurrent secondary spontaneous pneumothorax.

Picture of eliola via Pixabay

Dejonckheere, G, Herman, A, Baeck, M. Allergic contact dermatitis caused by synthetic rubber gloves in healthcare workers: Sensitization to 1,3‐diphenylguanidine is commonContact Dermatitis. 2019; 81: 167– 173. https://doi.org/10.1111/cod.13269

The frequency of allergic contact dermatitis has significantly increased in healthcare workers since the transition from latex to synthetic rubber gloves, with 1,3-diphenylguanidine being identified as the most frequently implicated allergen. The objective of this study is to highlight the role of 1,3-diphenylguanidine as the culprit allergen in contact allergies to synthetic rubber gloves, to propose recommendations for patch testing, and to discuss alternatives for sensitized subjects.

The article presents patch test data from healthcare workers who developed hand dermatitis after wearing rubber gloves and who reacted positively to glove samples and rubber additives were collected from September 2010 to December 2017 in a Belgian hospital. A total of 44 caregivers were included. Patch tests showed that:

  • 84% of the study population reacted positively to carba mix;
  • 86% reacted positively to 1,3-diphenylguanidine; and
  • 13 (30%) reacted positively to thiuram mix.
  • Half of the subjects reacted positively to gloves containing 1,3-diphenylguanidine, whereas none reacted to accelerator-free gloves.

Thus, the most commonly identified allergen was 1,3-diphenylguanidine, far ahead of thiurams, which were previously described as the most sensitizing accelerators. The use of 1,3-diphenylguanidine-free gloves is recommended. No subject reacted to gloves without accelerators, thus confirming their efficiency among accelerator-sensitized patients. We recommend that 1,3-diphenylguanidine be added to the European baseline series

Adeleh Shirangi, John Wright, Eve M Blair, Rosemary RC McEachan, Mark J Nieuwenhuijsen Occupational chemical exposures in pregnancy and fetal growth: evidence from the Born in Bradford Study Scandinavian Journal of Work, Environment & Health (2020)

The objective of this prospective birth cohort study is to evaluate the effect of occupational exposure to endocrine-disrupting chemicals (EDC) during pregnancy on inadequate fetal growth as measured by small-for-gestational age (SGA) and inadequate fetal growth measured by the percentage of optimal birth weight (POBW). The study also identified the maternal characteristics associated with an increased risk of exposure to EDC.

In total 4142 pregnant women who were in paid employment during pregnancy and participated in a population-based, prospective 2007-2011 birth cohort study, the Born in Bradford Study, were studied. Job titles were coded at 26-28 weeks` gestation at a 4-digit level according to 353 unit groups in the 2000 UK Standard Occupational Classification. They were then linked to expert judgment on exposure to each of ten EDC groups as assessed through a job exposure matrix (JEM).

The frequency of POBW<85 significantly increased for mothers exposed to pesticides [adjusted risk ratio (RRadj) 3.72, 95% confidence interval (CI) 1.40-9.91] and phthalates (RRadj 3.71, 95% CI 1.62-8.51). There was a 5-fold increase risk of SGA for mothers exposed to pesticides (RRadj 5.45, 95% CI 1.59-18.62). Veterinary nurses and horticultural trades were most frequently associated with exposure to pesticides while hairdressers, beauticians, and printing machine minders were associated with phthalates. The authors conclude that maternal occupational exposure to estimated concentrations of pesticides and phthalates is associated with impaired fetal growth.



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