August 2020 additions to NERDB (2)

August 2020 additions to NERDB (2)

NERDB is the New and emerging risks database. This bibliographic database is an initiative of Nicole Palmen and Annet Lenderink with the support of Modernet and is currently powered by Airtable.

More information on this database on the NERDB page

On the website we will publish from this month on regular updates on new disease – exposure combinations we added to the database. Currently, we have 261 entries. Ordered by year in which the abstract is published

unknown year6

Last new entries

Jelena Macan, Almenka Balenović, Rajka Turk, Independent contact allergy to bisphenol F epoxy resin: A case report Contact Dermatitis 02 October 2019

Diglycidyl ether of bisphenol A epoxy resin (DGEBA‐ER) is among the most prevalent occupational industrial contact allergens nowadays. Diglycidyl ether of bisphenol F epoxy resin (DGEBF‐ER) products are also widely used, but independent contact allergy to DGEBF‐ER has been considered rare.

A 48‐year‐old male painter, with total work experience of 17 years (last 12 years as a painter) is presented in this case report. For the last 1.5 year he had been applying anti-corrosive protection on oil tanks, which included sandblasting, washing with acetone, and spraying with two‐component epoxy‐based paint preheated at 30°C. After 5 months of performing these tasks, he developed eczema (erythema, itchy vesicles, induration) on his face, neck, hands, and forearms, which tended to diminish during periods off work.

The company’s occupational physician initiated diagnostic workup for suspected occupational skin disease. Patch tests with the European baseline series performed by a dermatologist had negative results, including for DGEBA‐ER. After analysis of the safety data sheets additional patch tests with 48 hours of exposure time, and readings at day (D) 2 and D3 were performed in the worker and two control subjects with the relevant paint provided from the workplace. The patient reacted ++/++ to 0.5% and +++/+++ to 1%, while no reaction was seen in both controls. Therefore, occupational allergic contact dermatitis, most likely caused by DGEBF‐ER was diagnosed and notified. Achange of workplace was arranged by the occupational physician.

Moura, Luiza Taciana Rodrigues de, Bedor, Cheila Nataly Galindo, Lopez, Rossana Veronica Mendoza, Santana, Vilma Sousa, Rocha, Talita Máira Bueno da Silveira da, Wünsch Filho, Victor, & Curado, Maria Paula. (2020). Occupational exposure to organophosphate pesticides and hematologic neoplasms: a systematic reviewRevista Brasileira de Epidemiologia23, e200022. Epub May 11, 2020.

Picture by Erich Westendarp via Pixabay

The authors’ objective was to update the findings of observational analytical studies on the association between occupational exposure to organophosphates and hematologic malignancies. They performed a systematic literature review. They included cohort and case-control studies, without limitation of publication time, in Portuguese and English. The articles were traced from June 2017 to July 2019 in PubMed, MEDLINE, LILACS, Web of Science, and Scopus databases. The qualitative bias risk assessment was performed using the Newcastle-Ottawa Scale and the Downs and Black Checklist. Results were presented according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA).

Seventeen studies evaluated as good/high methodological quality were eligible. Exposure to diazinon (1 cohort), phonophos (1 cohort), dichlorvos, crotoxiphos and famphur (1 case-control) was associated with leukemia, while exposure to organophosphate was associated to lymphomas (6 case-control); the risk of non-Hodgkin’s lymphoma was higher in those exposed to diazinon (1 control case) and malathion (3 control case) than non-exposed ones. Multiple myeloma occurred more commonly in organophosphate exposed than in non-exposed individuals (1 case-control). The authors conclude that occupational exposure to organophosphates increases the risk of hematologic malignancies, especially among individuals with longer exposure periods. Worker monitoring and exposure control measures are recommended.

Walters GI, Burge PS, Moore VC, Thomas MO, Robertson AS. Occupational asthma caused by peracetic acid-hydrogen peroxide mixture. Occup Med (Lond). 2019;69(4):294-297. doi:10.1093/occmed/kqz032

Healthcare practice in the UK has moved away from using aldehyde disinfectants for the decontamination of endoscopes, in part due to the risk of respiratory sensitization. Peracetic acid (PAA) in combination with hydrogen peroxide (HP) is a commonly used alternative. Nevertheless the authors describe a case of occupational asthma (OA) diagnosed at our specialist occupational lung disease clinic. It is caused by occupational exposure to PAA-HP mixture, used as a disinfectant in an endoscope washer-disinfector machine.

This is the case report: A 48-year-old man employed as a mycologist and environmental microbiologist at a Birmingham city hospital, UK, presented following an acute exposure to PAA-HP mixture causing lacrimation, burning optic pain and headache. He had also experienced symptoms suggestive of OA for the preceding 10 months, and the diagnosis was confirmed through OASYS analysis of serial peak expiratory flow measurements. He had been exposed to PAA-HP mixture whilst working in the endoscopy department for 12 months prior to the acute episode, and a subsequent specific inhalation challenge test was positive with a late asthmatic response to PAA-HP mixture.

Westberg, H., Hedbrant, A., Persson, A. et al. Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in Swedish iron foundries, in particular respirable quartz. Int Arch Occup Environ Health 92, 1087–1098 (2019).

Westberg et al. studied the relationship between inhalation of airborne particles and quartz in Swedish iron foundries and markers of inflammation and coagulation in blood. They used personal sampling of respirable dust and quartz for 85 subjects in three Swedish iron foundries. Stationary measurements were used to study the concentrations of respirable dust and quartz, inhalable and total dust, PM10, and PM2.5, as well as the particle surface area and the particle number concentrations. Markers of inflammation, namely interleukins (IL-1β, IL-6, IL-8, IL-10, and IL-12), C-reactive protein, and serum amyloid A (SAA) were measured in plasma or serum, together with markers of coagulation including fibrinogen, factor VIII (FVIII), von Willebrand factor and D-dimer.

The average 8-h time-weighted average air concentrations of respirable dust and quartz were 0.85 mg/m3 and 0.052 mg/m3, respectively. Participants in high-exposure groups with respect to some of the measured particle types exhibited significantly elevated levels of SAA, fibrinogen and FVIII. These observed relationships between particle exposure and inflammatory markers may indicate an increased risk of cardiovascular disease among foundry workers with high particulate exposure.



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