June 2021 additions to NERDB

June 2021 additions to NERDB

NERDB is the New and emerging risks database. This bibliographic database is an initiative of Nicole Palmen and Annet Lenderink with the support of Modernet and is currently powered by Airtable.

More information on this database on the NERDB page

On the website, we will publish regular updates on new disease-exposure combinations we added to the database. Currently, we have 300 entries. Ordered by year in which the abstract is published

19771201011
19881201110
19953201210
19971201313
19992201419
20021201527
20052201621
20061201735
20072201830
20085201951
20093202037
unknown year620215

Last new entries:

Photo by DESIGNECOLOGIST on Unsplash

Warshaw EM, Voller LM, Silverberg JI, DeKoven JG, Atwater AR, Maibach HI, Reeder MJ, Sasseville D, Belsito DV, DeLeo VA, Fransway AF, Fowler JF Jr, Taylor JS, Pratt MD, Mathias T, Marks JG Jr, Zug KA, Zirwas MJ. Contact Dermatitis Associated With Nail Care Products: Retrospective Analysis of North American Contact Dermatitis Group Data, 2001-2016. Dermatitis. 2020 May/Jun;31(3):191-201. doi: 10.1097/DER.0000000000000583. PMID: 32355091.

Ingredients in nail care products may lead to allergic and/or irritant contact dermatitis. The aims of this study were to determine the frequency of contact dermatitis associated with nail care products, characterize associated body sites, and describe causative allergens. A retrospective analysis was conducted with the North American Contact Dermatitis Group data between 2001 and 2016.

Of the 38,775 patients tested, 769 (2.0%) had: 1) more than 1 allergic patch test reaction associated with a nail care product (n = 746), 2) irritant contact dermatitis associated with a nail care product (n = 14), or 3) both (n = 9). Primary body sites included the face (43.0%) and hands (27.6%). The top 5 allergens were (2-hydroxyethyl methacrylate (273/482, 56.6%), methyl methacrylate (210/755, 27.8%), ethyl acrylate (190/755, 25.2%), ethyl-2-cyanoacrylate (12/175, 6.9%) and tosylamide (273/755, 36.2%). Frequency of allergy to 2-hydroxyethyl methacrylate (P = 0.0069) and ethyl acrylate (P = 0.0024) significantly increased over the study period, whereas allergy secondary to tosylamide significantly decreased (P < 0.0001).

As long-lasting nail techniques become widespread, the prevalence of contact dermatitis to nail care products is expected to increase. Almost one-fifth of nail care product-associated allergens would have been missed without additional screening allergens beyond the North American Contact Dermatitis Group series, underscoring the need for testing to a broad array of allergens.

Touati N, Chiriac AM, Bourrain JL, Demoly P. An Unusual Case of Occupational Rhinitis. J Investig Allergol Clin Immunol. 2020 Jun;30(3):207-208. doi: 10.18176/jiaci.0484. PMID: 32571765.

The authors present the case of a 35-year-old man who reported rhinitis, anosmia, and epistaxis with no bronchial or cutaneous signs that had first appeared some months previously. Symptoms seemed to be associated with the patient’s occupation, since they disappeared for a few days during vacations and recurred within a few days after returning to work. He also reported exacerbations 4 to 5 hours after consuming wine. The patient had been working for many years in a coffee factory making coffee pods without wearing masks or protective gloves and was regularly exposed to coffee dust and paper filter systems, which included sulfur dioxide (SO2) and sulphites (SO3) at concentrations below regulatory standards.

Maritati, F., Peyronel, F., Fenaroli, P., Pegoraro, F., Lastrucci, V., Benigno, G.D., Palmisano, A., Rossi, G.M., Urban, M.L., Alberici, F., Fraticelli, P., Emmi, G., Corradi, M. and Vaglio, A. (2021), Occupational exposures and smoking in eosinophilic granulomatosis with Polyangiitis (Churg-strauss syndrome). Arthritis & Rheumatology. Accepted Author Manuscript. https://doi.org/10.1002/art.41722

Eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss syndrome) is a rare anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Environmental agents and occupational exposures may confer susceptibility to EGPA, but data are scarce. The authors investigated the association between occupational exposures (e.g., silica, farming, asbestos, organic solvents) and other environmental agents (e.g., smoking) and the risk of EGPA. One-hundred and eleven newly diagnosed EGPA patients and 333 controls matched for age, sex and geographic area of origin were recruited at a national referral centre for EGPA. Exposures were assessed using a dedicated questionnaire administered by a blinded specialist in occupational medicine.

Exposures to silica [OR 2.79 (95% CI 1.55-5.01), p=0.001], organic solvents [OR 3.19 (95% CI 1.91-5.34), p<0.001], and farming [OR 2.71 (95% CI 1.71-4.29), p<0.001] were associated with an increased risk of EGPA. Co-exposure to silica and farming yielded an OR of 9.12 (95% CI 3.06-27.19) (p<0.001), suggesting a multiplicative effect between these two exposures. Smoking (current and former smokers combined) was significantly less frequent among cases than among controls [OR 0.49 (95% CI 0.29-0.70), p<0.001)]. The pack-year index was also lower among cases [OR 0.96 (95% CI 0.94-0.98), p<0.001]. The associations with silica and farming were primarily aligned with ANCA-positive EGPA, those with smoking and solvents with ANCA-negative EGPA. The authors conclude that the environment influences the susceptibility to EGPA: exposures to organic solvents, silica, and farming are associated with an increased risk of the disease, while smoking with a lower risk. These exposures seem to have distinct effects on EGPA subsets.

Villalobos V, Rial MJ, Pastor-Vargas C, Esteban I, Cuesta J, Sastre J. Occupational Asthma and Rhinitis due to Yellow and Red Henna in a Hairdresser. J Investig Allergol Clin Immunol. 2020 Apr 24;30(2):133-134. doi: 10.18176/jiaci.0453. Epub 2019 Sep 18. PMID: 31530513. https://pubmed.ncbi.nlm.nih.gov/31530513/

The authors present the case of a 30-year-old female hairdresser who developed rhinitis and occupational asthma despite no prior relevant medical history. One year ago, new botanical hair dyes containing Cassia obovata (yellow henna) and L inermis (red henna) were introduced in her workplace. When handling
the products, the patient complained of hives in the areas of exposure, as well as rhinorrhea, pruritus (eyes and nose), and dyspnea. On one occasion, she required emergency care due to bronchospasm.

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