NERDB is the New and emerging risks database. This bibliographic database is an initiative of Nicole Palmen and Annet Lenderink with the support of Modernet and is currently powered by Obvibase.

More information on this database on the NERDB page

On the website we will publish from this month on regular updates on new disease – exposure combinations we added to the database. Currently, we have 211 entries. Ordered by year in which the abstract is published

19771201011
1988120119
19953201210
19971201313
19992201419
20021201527
20052201621
20061201735
20072201827
20085201912
20093unknown year6

Last new entries

Laura Georgiana Moise, Sonia Bădulici, Agripina Rașcu, Alexandra Maria Rașcu Acrylic sculpting nails, an occupational hazard for contact dermatitis. Case reports and review of the literature RJOM 2019, Vol. 70, No. 1

Acrylates are plastic materials formed by the polymerization of monomers, which are recognized as powerful sensitizers that may cause allergic contact dermatitis both in the occupational and non-occupational environment. In the occupational setting, the most exposed workers are the dentists, dental technicians, prosthesis technicians, printers, painters, fiberglass workers, and nail technicians. We describe four cases of occupational allergic contact dermatitis in nail technicians caused by acrylic compounds that illustrate numerous clinical manifestations. Clinical manifestations ranged from edema, erythema, scaling and fissuring fingertips to erythematous patches around the chin, mandible, and abdomen. Patch testing results revealed positive reaction to 2-hydroxyethyl methacrylate in all patients. Of the four patients, two changed jobs, one stopped exposure because of pregnancy and one patient continued working, showing no improvement, despite undergoing treatment. These cases underline the importance of improvement of preventive measures in the workplace.

Moshe S, Krakov A P.2.17 Case report: three occupational diseases in a nail technician Occupational and Environmental Medicine 2019;76:A92.

In cosmetics, acrylic glues are used to apply nail and eyelash extensions. Acrylates are highly irritant materials and may cause local irritation (Contact Dermatitis – CD), respiratory irritation (Asthma) and systemic irritation (Urticaria). This case report describes these three occupational diseases. A 48-year-old female, normally healthy, has been working in the nail beauty field for 11 years. Lately, following an increase of work, she started coughing every morning and feeling shortness of breath which was worsen at the start of work and improved on vacations. In addition, the patient suffered from skin tenderness in her fingers. An examination of the hands showed a typical picture of CD in left-hand fingers 4–5. Specific Patch Tests showed sensitivity to Hydroxyethyl Methacrylate and Hydroxypropyl Methacrylate. A methacholine challenge test showed a 22% decrease in FEV1 at 3.94 μmol methacholine (i.e. positive test). The patient performed a Peak Expiratory Flow test (PEF). After a week in the nail salon, her respiratory and dermatological status worsened greatly, including the development of contact urticaria. She was instructed to stop immediately the exposure and start taking p/o steroids. Due to her 3 occupational diseases, she was removed from work and later was recognized as having 3 occupational disease by the Israeli National Insurance which supported her vocational rehabilitation. Acrylic glues are hazardous agents which can cause several occupational diseases and require occupational environment monitoring yearly according to Israeli regulations. The TLV-TWA is 2ppm. Small private businesses like the patients‘ place don’t perform environmental monitoring or use personal or environmental protective equipment which endangers its workers (usually low social class women) who are not aware of the dangers in this industry. More public attention should be given to the risk in this industry.

Min-Seok, Kim; Sang-Gil, Lee; Jae Yun Kim; Mo-Yeol Kang Maculopathy from an accidental exposure to welding arc BMJ Case Reports; London Vol. 12, Iss. 2,  (Feb 2019). DOI:10.1136/bcr-2018-227677

Welding light can cause photic retinal injury. We report binocular maculopathy induced by brief exposure to electric arc welding light in a patient who could not be equipped with a protective device because of narrow space. A 47-year-old man performed electric arc welding for approximately 10–15min without wearing a protective device because of narrow space and subsequently experienced eye discomfort and decreased visual acuity. At the initial visit, his best-corrected visual acuity was 0.5. Fundus examination, optical coherence tomography (OCT) and multifocal electroretinogram (mfERG) were performed. OCT showed disruption in the ellipsoid zone, and mfERG amplitudes in the central 10° were markedly reduced in both eyes. The decrease in visual acuity had been noted for at least 18 months. Using the proper protective device is essential in welding, despite short time periods of work. For patients with welding induced photokeratitis, doctors should also consider the possibility of photic retinal injury.